Key developments in molecular biology, bioinformatics and drug development have positioned Molecular Stethoscope to leverage cf-mRNA to create accurate and clinically useful diagnostic tests.
Technology
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Technology behind Molecular Stethoscope
- Molecular Stethoscope has developed new methods for characterizing highly complex, rare fragments of mRNA in blood
- Evolution of knowledge around pathways and novel computational techniques for processing and interpreting big data sets has enabled the formation of the Molecular Stethoscope proprietary database
- Proliferation of expensive and highly effective targeted therapeutics has created an urgent need for diagnostics to facilitate informed selection
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RNA Isolation
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Quantification
Sequencing and qPCR
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Identification
Tissue specific gene expression database
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Separation
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Algorithm development by machine learning
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Deconvolution of disease state
References:
Topol E, Quake SR (2015)
A stethoscope for the next 200 years. The Wall Street Journal http://www.wsj.com/articles/eric-topol-and-stephen-r-quake-a-stethoscope-for-the-next-200-years-1420242913
Koh W, et al. (2014)
Noninvasive in vivo monitoring of tissue-specific global gene expression in humans. PNAS 111(20):7361–7366.
Damani S, et al. (2012)
Characterization of circulating endothelial cells in acute myocardial infarction. Sci Transl Med. 4(126):126ra33.