The development of genomic measurement technologies and reference databases such as the Human Genome Project (2000) enabled the use of blood to reliably obtain genetic information.
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Gene expression profiling arms us with information
Based on this, Dr. Stephen Quake (Molecular Stethoscope co-founder), Professor of Bioengineering at Stanford University and co-president at the Chan Zuckerberg Biohub, developed the first non-invasive prenatal test for Down Syndrome and other aneuploidies.
Dr. Quake’s work has led to the explosive growth in non-invasive prenatal testing based on cf-DNA. Many other areas of minimally invasive testing have also been enabled by this approach, including tests for cancer, complex infectious disease and organ transplant.
cf-mRNA Tells a Tissue-Specific Story
Taking these findings further, Dr. Quake’s lab performed a genome-wide analysis of cf-mRNA and showed that tissue-specific signatures from most major organs can be monitored in blood.
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Dr. Eric Topol (Molecular Stethoscope co-founder) showed that related blood-based mRNA measurements can be used for cardiovascular applications. Dr. Eric Topol is the Executive Vice President of the Scripps Research Instutute and the Founder and Director of Scripps Translational Science Institute, La Jolla, California.
His most recent book, The Patient Will See You Now explores how smart phones, big data, and technology are combining to democratize health care.
Molecular Stethoscope: Circulating mRNA Key to Improving Patient Health
Together, Dr. Quake and Dr. Topol’s discoveries created the foundation of Molecular Stethoscope’s approach and technology.
Molecular Stethoscope is now taking these groundbreaking insights and applying them to patient health.
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